The 17 Sustainable Development Goals (SDGs) set out in the United Nations 2030 Agenda summarise the major challenges for our world. Their implementation requires important contributions from Science, Technology and Innovation (STI) policy. However, it is clear that addressing the SDGs is also a challenge for STI policy, since business as usual will not be sufficient. Within the Transformative Innovation Policy Consortium (TIPC) members have embraced this challenge, working together transnationally to provide a new transformative foundation for STI policy. They recognize that it requires openness and willingness to explore new transformative principles and ideas. . This briefing proposes a way of viewing the implementation of the SDGs from a Transformative Innovation Policy (TIP) perspective, which is simultaneously different and complementary to the ongoing process of mainstreaming SDGs into current policies. TIP offers an integrated and systems approach which targets the underlying connections and trade-offs among the SDGs. Rather than treating the SDGs as individual targets or seeing them as missions, it focuses on transformation processes that format specific outcomes as defined by the entire collection of SDGs. A Transformative Innovation Policy approach offers potentially game-changing opportunities in the definition of a national implementation strategy for Agenda 2030.