We are proposing a session that reports on two new flagship policy initiatives by international organisations – the OECD and the European Commission’s Joint Research Centre – which are unique in sharing explicitly transformative framings and objectives. The OECD’s “S&T Policy 2025” initiative aims to provide an overarching vision and framework for STI policymakers to rethink, redesign and implement a new generation of STI policies. Given the urgent need to set STI policy on pathways to contribute to long-term socio-technical transitions, the initiative will aim to articulate short-term, positively normative ‘stretch targets’ (to 2025) for the STI policy community to aim at achieving. The JRC’s “Innovation strategies for sustainability” (S4) initiative seeks to accelerate the transition to sustainability while creating local jobs in the new green and digital economy. It will gather evidence through a series of system-level policy reviews to provide concrete policy advice to cities, regions and national governments on designing and implementing S4 strategies. The two initiatives draw inspiration from transformative innovation policy literature and build on many years of fruitful cooperation between the OECD and the European Commission. The aim of this proposed session is to engage in a critical discussion with academics and policy practitioners and facilitate international learning.