Marry-Anne Phasha

Biography

Dr Dr Marry-Ann Ntanyane Phasha is a University of Pretoria graduate with an undergraduate degree in Human Genetics, where she majored in genetics and physiology. She did her honours, masters and PhD in Human Physiology. In her thesis, the prevalence of FXIII-A single nucleotide variants and miR-155-5p and FXIII-A levels in coronary heart disease patients with type 2 diabetes mellitus, she demonstrated that in the presence of FXIIIA Tyr204Phe and Glu651Glu variants, patients had a reduced risk of T2DM, while the risk was higher for coronary heart disease in the presence of the Tyr204Phe variant. Clot kinetics was significantly prolonged in T2DM, CHD and comorbid patients, and the presence of genotypic variants, the coagulation phenotype was also affected. Coagulation FXIII-A mRNA and protein levels were most affected in patients with T2DM. The hypothesis that miR-155-5p levels is associated with FXIII-A levels was disproved. This was the first study which assessed the prevalence of seven genetic variants in FXIII-A in the South African population. She is doing her postdoctoral fellowship with Graduate School of Technology Management (GSTM), Department of Engineering and Technology Management, and a new member of TIAH_TIPC. Her research project is on Science, Technology and Innovation (STI) Policy for Transformative change. is a University of Pretoria graduate with an undergraduate degree in Human Genetics, where she majored in genetics and physiology. She did her honours, masters and PhD in Human Physiology. In her thesis, the prevalence of FXIII-A single nucleotide variants and miR-155-5p and FXIII-A levels in coronary heart disease patients with type 2 diabetes mellitus, she demonstrated that in the presence of FXIIIA Tyr204Phe and Glu651Glu variants, patients had a reduced risk of T2DM, while the risk was higher for coronary heart disease in the presence of the Tyr204Phe variant. Clot kinetics was significantly prolonged in T2DM, CHD and comorbid patients, and the presence of genotypic variants, the coagulation phenotype was also affected. Coagulation FXIII-A mRNA and protein levels were most affected in patients with T2DM. The hypothesis that miR-155-5p levels is associated with FXIII-A levels was disproved. This was the first study which assessed the prevalence of seven genetic variants in FXIII-A in the South African population. She is doing her postdoctoral fellowship with Graduate School of Technology Management (GSTM), Department of Engineering and Technology Management, and a new member of TIAH_TIPC. Her research project is on Science, Technology and Innovation (STI) Policy for Transformative change.